uso shot Posted in U Best definition uso shotdrugs A perpetually flowing sot, in which the drinker chugs hard alcohol, while his drunk friends count and chant WE OVER HERE GETTIN LOADED! Sweet mother of Jesus mclovin just took a 25 second uso shot! you full it??? How satisfied are you with the definition? Looking for uso shot meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 65 times.