Upshot Nuthole Posted in U Best definition Upshot Nuthole Codename for a series of two mid-altitude nuclear tests conducted by the US military outside of Las Vegas in the 60’s. The Upshot Nuthole explosions could be heard in Las Vegas. How satisfied are you with the definition? Looking for Upshot Nuthole meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 29 times.