upperclass syndrome Posted in U Best definition upperclass syndrome when an upper classmen spends most of his time trying to get with younger girls, but usually doesnt succeed. Garrett is always spittin at the sophmore girls, but doesn’t get much. He has upperclass syndrome. How satisfied are you with the definition? Looking for upperclass syndrome meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 96 times.