Upful Posted in U Best definition Upful Jamaican slang for positive feelings. You’re so upful. (you’re so cheerful.) Upful: define #2 upful Positive. Confident. Evolving. Kind. Live and full of life. Joy. Jubilant. Exalted. Blissful. Have an upful day! How satisfied are you with the definition? Looking for Upful meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 112 times.