Best definition
A reference to Male Genitals and Anus based on context.

ex. 1: Hey babe, wanna do it in the nis? (anus)

ex. 2: Dude, look at my giant nis! (penis or anus)

ex. 2: She totally just polished my nis (penis)
Nis: define #2
Niš is a city in Serbia and one of the oldest cities in the Balkans, and has from ancient times been considered a gateway between the East and the West.
Constantine I, ruler of the Byzantium empire (4th century) was born at Naissus, (today called Nis, Serbia)
Nis: define #3
Shorthand for penis.
Hey Melissa, are you gunna get some of that ‘nis tonight?
Nis: define #4
another word for penis
All these girls on my nis
Nis: define #5
“Non-Interactive Scene”

Primarily used in the games industry to describe a cutscene where the players control of the character has been temporarily deactivated to watch a series of events.
Dude, did you see that NIS where that zombie jumps out the hallway and knocks you down the stairs? I totally papped myself.
Nis: define #6
1) of or relating to your personal space

2) an object or task that you cannot describe with English words

Other variation: nis-nis

“She was all up in my nis.”


“We’ll do the nis-nis and then get a sandwich.”
Nis: define #7
A shortened, slang version of penis. Meant to be in the style of ridiculous 1980s slang most likely said by some in the Valley of California.

Origin: South Side of Chicago neighborhood Mount Greenwood

“Ah man, she hit me in the nis!”
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