NEDF Posted in N Best definition NEDF 1.Other wise known as New England Despair Faction, NEDF is the New England Section of AFI’s elite fan club, The Despair Faction. 1. Are you going to the NEDF meetup? How satisfied are you with the definition? Looking for NEDF meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 80 times.