Muppetesque Posted in M Best definition Muppetesque Adjective describing a person who, as a result of extensive plastic surgery, now looks more like a muppet than a human. That Real Housewife has had so much plastic surgery, she looks positively muppetesque. How satisfied are you with the definition? Looking for Muppetesque meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 118 times.