Muddafuck Posted in M Best definition Muddafuck an exclamation of extreme dislike, disdain, or unapproval of something. Also used as a very derrogatory curse Muddafuck bey i dont like that bitch How satisfied are you with the definition? Looking for Muddafuck meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 44 times.