monoprotic Posted in M Best definition monoprotic 1. An expression of approval, similar in nature to “sick” or “weak”. 2. An acid having only one dissociable proton. OMG that’s sooooooooooo monoprotic. How satisfied are you with the definition? Looking for monoprotic meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 29 times.