Mofonious Posted in M Best definition Mofonious A heinous act, having been perpetrated by a “mofo” Or, something unfortunate that occurs. “Man, that bag of flaming dog doo on your doorstep is MOFONIOUS” How satisfied are you with the definition? Looking for Mofonious meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 71 times.