Mizzissippi Posted in M Best definition Mizzissippi This is when you have reached an all time low. Way worse than Mizz Town. You have no idea which way to turn. FML. my life sucks, im so Mizzissippi right now How satisfied are you with the definition? Looking for Mizzissippi meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 13 times.