Mfuki Posted in M Best definition Mfuki It is an acronym that means: Motha fucka you know it. Mostly used in instant messages and online language. Lorena said:”Hey Marcelo is really cool!” Liz said: “MFUKI!!!!” How satisfied are you with the definition? Looking for Mfuki meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 13 times.