Melsa Posted in M Best definition Melsa Best person you could ever meet. Smart +Funny+Awesome = a MELSAIf you ever meat a MELSA you will die (in a good way) Melsa is da best . via giphy How satisfied are you with the definition? Looking for Melsa meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 73 times.