Me Duh Posted in M Best definition Me Duh One of the simplest jokes to accomplish referring to your (if a male) genitals. guy1: Yo, you got the 4-5-4 box? guy2: The what? guy1: Me duh! How satisfied are you with the definition? Looking for Me Duh meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 43 times.