mcduffie Posted in M Best definition mcduffiedrugs (V) To consume a massive amount of alcohol, then vomit, using your shirt as a pouch to catch most of the puke. Last night I was chillin on the couch drinkin’ some icehouse, and I pulled a mcduffie. How satisfied are you with the definition? Looking for mcduffie meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 29 times.