Man-Sized Handshake Posted in M Best definition Man-Sized Handshake The act of grasping another man’s hand, in hopes of sexual relations. A homeless man walks up to you in a McDonald’s and asks if he can give you a Man-Sized Handshake. How satisfied are you with the definition? Looking for Man-Sized Handshake meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 29 times.