It may assume several meaning depending on the situation.
The origin of the
exclamation come from the beginning of times, where Madonna got pregnant by the Mule and not from Giuseppe, her husband, who was the first to say ‘Madonna Puttana’
moeghea madonna puttana !
Please shut up!
ehh madonna puttana !
What have you done?
Varda madonna puttana !
I did know it! It happened.
ehh Madonna (stra)puttana dio can!
We have (serious) trouble.
Chi xe sta? A madonna puttana ?
Who did it? It wasn’t you, was you?