L.U.P.O.S. Posted in L Best definition L.U.P.O.S. (loo-pus) n – Abbreviated form for Lazy, Useless, Piece of Shit. Ernest is such a L.U.P.O.S., all he does is sleep all day. How satisfied are you with the definition? Looking for L.U.P.O.S. meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 27 times.